Table IV.
Pharmacokinetic parameters in brain following intravenous administration of 3 mg/kg C8-DALDA solution or nanoemulsion in mice
| PK Parameter | Solution Dosing* | Nanoemulsion Dosing* | units |
|---|---|---|---|
| AUC 0-∞ | 104,634 | 325,851 | ng.min/g |
| MRT | 145.4 | 198.4 | min |
| λz | 0.00640 | 0.00396 | 1/min |
| t1/2 λz | 108.3 | 174.9 | min |
n= 3, two-tailed unpaired homoscedastic t-test, p< 0.05