Table 3.
Mean Degradation Characteristics of Composite Formulations in Standard PBS Over 28 Days. Mean values for the swelling ratio and the % mass remaining were calculated by averaging the measured values for each formulation over 28 days. For each property, values not connected by the same letters are significantly different.
Formulation | PEG chain MW | GMP Crosslinking Extent | DBR | Crosslinker Type | Mean Swelling Ratio | Mean Mass Remaining (%) |
---|---|---|---|---|---|---|
35kDA60:10 | 35,000 | 10 mM | 60 | PEGDA | 13.4±0.2b | 55.9±1.0c |
35kDA40:10 | 35,000 | 10 mM | 40 | PEGDA | 17.3±0.8a | 47.5±2.4d |
10kDA60:10 | 10,000 | 10 mM | 60 | PEGDA | 5.4±0.1c | 89.3±1.3a |
10kDA40:10 | 10,000 | 10 mM | 40 | PEGDA | 5.9±0.1c | 82.8±1.4a |
10kMB60:10 | 10,000 | 10 mM | 60 | MB | 13.2±0.4b | 67.3±2.0b |
10kMB40:10 | 10,000 | 10 mM | 40 | MB | 16.6±0.5a | 67.6±2.3b |
35kDA60:40 | 35,000 | 40 mM | 60 | PEGDA | 13.6±0.3b | 55.7±1.5c, d |
35kDA40:40 | 35,000 | 40 mM | 40 | PEGDA | 17.2±0.4a | 56.2±1.6c |
10kDA60:40 | 10,000 | 40 mM | 60 | PEGDA | 5.6±0.2c | 89.6±1.3a |
10kDA40:40 | 10,000 | 40 mM | 40 | PEGDA | 6.0±0.2c | 86.2±1.5a |
10kMB60:40 | 10,000 | 40 mM | 60 | MB | 14.1±0.4b | 70.2±2.1b |
10kMB40:40 | 10,000 | 40 mM | 40 | MB | 17.9±0.6a | 63.6±2.3b, c |