Table 4.
Mean Degradation Characteristics of Composite Formulations in Col-PBS Over 28 Days. Mean values for the swelling ratio and the % mass remaining were calculated by averaging the measured values for each formulation over 28 days. For each property, values not connected by the same letters are significantly different.
Formulation | PEG chain MW | GMP Crosslinking Extent | DBR | Crosslinker Type | Mean Swelling Ratio | Mean Mass Remaining (%) |
---|---|---|---|---|---|---|
35kDA60:10 | 35,000 | 10 mM | 60 | PEGDA | 18.1±0.8b | 43.1±2.3f, g |
35kDA40:10 | 35,000 | 10 mM | 40 | PEGDA | 26.7±1.5a | 37.4±2.7g |
10kDA60:10 | 10,000 | 10 mM | 60 | PEGDA | 6.4±0.2d | 82.1±1.4a |
10kDA40:10 | 10,000 | 10 mM | 40 | PEGDA | 6.9±0.2d | 75.9±1.4a, b |
10kMB60:10 | 10,000 | 10 mM | 60 | MB | 13.3±0.3c | 64.5±2.1c, d |
10kMB40:10 | 10,000 | 10 mM | 40 | MB | 19.2±0.6b | 56.5±2.2d, e |
35kDA60:40 | 35,000 | 40 mM | 60 | PEGDA | 13.9±0.7c | 47.3±2.4f |
35kDA40:40 | 35,000 | 40 mM | 40 | PEGDA | 19.6±0.5b | 50.4±1.5e, f |
10kDA60:40 | 10,000 | 40 mM | 60 | PEGDA | 5.9±0.2d | 84.3±1.2a |
10kDA40:40 | 10,000 | 40 mM | 40 | PEGDA | 6.6±0.3d | 79.4±1.4a |
10kMB60:40 | 10,000 | 40 mM | 60 | MB | 14.2±0.4c | 68.2±1.9b, c |
10kMB40:40 | 10,000 | 40 mM | 40 | MB | 18.6±0.7b | 61.3±1.8c, d |