Table 2.

Factors Associated with the BMI Trajectory from Age 25 Years to Late Life in Men: Final Model Results

	TwinGene			SATSA
	Estimate	Standard Error	P-value	Estimate	Standard Error	P-Value
Intercept (age 65 years)	24.904	0.457	<0.001	24.177	0.882	<0.001
Slope A (age 25–65 years)	0.029	0.011	0.011	0.017	0.021	0.410
Slope B (age >65–80 years)	−0.007	0.021	0.727	0.046	0.026	0.084
Slope C (age >80 years)	-	-	-	−0.178	0.055	0.001
Demographic
Assessment bias	−0.206	0.039	<0.001	−0.298	0.138	0.031
Cohort	0.615	0.358	0.086	2.303	0.490	<0.001
Cohort*Slope A	0.026	0.009	0.004	0.052	0.012	<0.001
Cohort*Slope B	0.027	0.020	0.193	−0.009	0.036	0.792
Cohort*Slope C	-	-	-	-	-	-
Education	−0.037	0.156	0.814	−0.503	0.411	0.221
Education*Slope A	0.020	0.004	<0.001	−0.010	0.011	0.345
Education*Slope B	−0.038	0.017	0.022	−0.023	0.035	0.497
Education*Slope C	-	-	-	0.231	0.108	0.033
Genetic
OGRS	0.085	0.019	<0.001	0.148	0.055	0.007
OGRS*Slope A	<0.001	<0.001	0.251	0.003	0.001	0.038
Midlife lifestyle factors
Exercise	−0.072	0.101	0.473	−0.356	0.333	0.285
Smoking	0.270	0.125	0.031	−0.152	0.432	0.724
Smoking*Slope A	0.010	0.003	0.002	−0.008	0.012	0.528
Alcohol	0.601	0.287	0.037	0.574	0.687	0.403
Alcohol*Slope A	0.024	0.008	0.002	0.043	0.019	0.025
Diseases (across the study period)
T2DM	1.966	0.184	<0.001	2.380	0.510	<0.001
T2DM*Slope A	0.023	0.005	<0.001	0.041	0.013	0.002
T2DM*Slope B	−0.008	0.022	0.727	−0.107	0.041	0.009
CVD	0.164	0.042	<0.001	0.301	0.219	0.170
Cancer	−0.358	0.210	0.089	0.877	0.508	0.085
Cancer*Slope A	−0.013	0.006	0.015	−0.006	0.014	0.669
Respiratory diseases	0.570	0.209	0.006	−0.031	0.461	0.947
Respiratory diseases*Slope A	0.017	0.005	0.001	−0.008	0.012	0.497

Slope A (25 years to <65 years), slope B (≥65 years to <80 years), and slope C (≥80 years)