Table II.
Biophysical Characteristics of Curcumin-Loaded PEG5K-FTS2(L) Micelles and Free Micelles
| Micelles | Molar ratio | Particle size (nm) | PDI | DLE (%) | DLC (%) | Stability (h) |
|---|---|---|---|---|---|---|
| PEG5K-FTS2(L) | – | 19.8 ± 0.1 | 0.266 | – | – | – |
| PEG5K-FTS2(L): curcumin | 0.5:1 | 24.2 ± 0.6 | 0.139 | 75.2 | 11.8 | 2 |
| 1:1 | 20.8 ± 1.0 | 0.332 | 89.1 | 5.9 | 4 | |
| 2.5:1 | 19.0 ± 1.3 | 0.239 | 98.5 | 2.4 | 36 | |
| 5:1 | 22.9 ± 1.2 | 0.080 | 97.6 | 1.2 | 96 | |
| 10:1 | 21.3 ± 0.3 | 0.145 | 98.2 | 0.6 | 180 |
Curcumin concentration in micelles was 1 mg/ml. Blank micelles concentration was 20 mg/ml. Values reported at the means ± SEM
PDI polydispersity index, DLE drug-loading efficiency, DLC drug-loading capacity