Fig. 1.

Schematics of the PK models used to characterize the disposition of A1mcMMAF ADC. a A modified two compartment PK model used to characterize the plasma PK of total mAb and ADC simultaneously. b A combined PK model consisting of 2 integrated two compartment models to characterize the PK of ADC and released payload simultaneously. c A multi-scale mechanistic ADC tumor disposition PK model, capable of characterizing and predicting the PK of ADC and released payload in plasma and the tumor compartment. Note: Please refer to the “Materials and Methods” section and Table I for detailed description of the symbols used in the schematics