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. 2014 Mar 1;16(3):452–463. doi: 10.1208/s12248-014-9576-9

Fig. 3.

Fig. 3

a Observed plasma PK of total mAb and ADC obtained after administration of A1mcMMAF in H1975 tumor bearing mice at 3 mg/kg dose level. b Observed plasma PK of total mAb and ADC obtained after administration of A1mcMMAF in MDA-MB-361/DYT2 tumor bearing mice at 3 mg/kg dose level. c Observed and model predicted tumor PK of total mAb, ADC, and released payload, and plasma PK of released payload, obtained after administration of A1mcMMAF in H1975 tumor bearing mice at 3 mg/kg dose level, superimposed over each other. d Observed and model predicted tumor PK of total mAb, ADC, and released payload, and plasma PK of released payload, obtained after administration of A1mcMMAF in MDA-MB-361/DYT2 tumor bearing mice at 3 mg/kg dose level, superimposed over each other