Table II.

Estimated or Literature Derived Parameter Values Employed for Simulating the ADC Tumor Disposition PK Model

Parameter	Value	Unit	Source
CL mAb	0.021	L/day/kg	Estimated
V1 mAb	0.069	L/kg	Estimated
CLD mAb	0.089	L/day/kg	Estimated
V2 mAb	0.085	L/kg	Estimated
k dis	0.29	1/day	Estimated
CL ADC	0.0426	L/day/kg	Estimated
V1 ADC	0.0666	L/kg	Estimated
CLD ADC	0.0678	L/day/kg	Estimated
V2 ADC	0.0918	L/kg	Estimated
CL PL	74.8	L/day/kg	Estimated
V1 PL	2.22	L/kg	Estimated
CLD PL	485	L/day/kg	Estimated
V2 PL	63.83	L/kg	Estimated
R Cap	8	Μm	From Ref (8)
R Krogh	75	Μm	From Ref (8)
P ADC	334	μm/day	From Ref (8)
D ADC	0.022	cm2/day	From Ref (8)
ε ADC	0.24	Unitless	From Ref (8)
Ag Total	104 (H1975), 66.4 (MDA-MB-361/DYT2)	nM	Measured
k on ADCAntigen	23.2	1/nM/day	Measured
k off ADCAntigen	21.6	1/day	Measured
k intAg	4.2	1/day	Measured
R Tumor	0.5	cm	Measured
P PL	2.1E + 04	μm/day	From Ref (8)
D PL	0.25	cm2/day	From Ref (8)
ε PL	0.44	Unitless	From Ref (8)
k intPL	9.66	1/day	From Ref (2)
k on PLTubulin	0.73	1/nM/day	Based on Kd of 18 nM
k off PLTubulin	13.1	1/day	From Ref (2)
k outPL	1.1	1/day	Assumed similar to MMAE, from Ref (2)
Tubulin Total	65	nM	From Ref (2)
DAR 0	4.0	Unitless	Measured