From literature reports (references in parenthesis) |
K, hydraulic conductivity of tumor tissue in periphery |
2.5 × 10−7 cm2/mmHg/s (39) |
L
p, hydraulic conductivity of vessel wall |
1.86 × 10−6 cm/mmHg/s (39) |
S
v/V, vessel surface area/unit tissue volume in tumor periphery |
200 cm2/cm3 (37) |
P
d, permeability of vessel wall to paclitaxel |
2.0 × 10−5 cm/s (68) |
P
v, microvascular hydrostatic pressure |
3.0 mmHg (43) |
P
ip, pressure in intraperitoneal cavity |
−0.2 mmHg (57) |
πi, osmotic pressure of interstitial proteins |
19.8 mmHg (39) |
πv, osmotic pressure of plasma proteins |
17.3 mmHg (39) |
Calculated |
D
int, drug diffusion coefficient in tumor interstitium |
0.77 × 10−6 cm2/s |
D′0, drug diffusion coefficient in tumor periphery |
0.27 × 10−6 cm2/s |
σ
v, reflection coefficient of vessels for plasma protein |
0.0012 |
σ
p, reflection coefficient of vessels for paclitaxel |
2.5 × 10−5
|
Experimentally determined |
A, intercept of distribution phase in C
ip,total
vs. time plot |
415 μM |
B, intercept of elimination phase in C
ip,total
vs. time plot |
7.34 μM |
A′, intercept of distribution phase in C
plasma,total
vs. time plot |
7.18 μM |
B′, intercept of elimination phase in C
plasma,total
vs. time plot |
0.35 μM |
α
ip, rate constant of distribution phase in C
ip,total
vs. time plot |
0.41/h |
β
ip, rate constant of elimination phase in C
ip,total
vs. time plot |
0.16/h |
α
p, rate constant of distribution phase for C
plasma,total
vs. time plot |
0.67/h |
β
p, rate constant of elimination phase for C
plasma,total
vs. time plot |
0.09/h |
k
p, rate constant for drug absorption into blood |
0.95/h |
B
max, maximum cell binding capacity for paclitaxel |
81.8 μM |
k
d, equilibrium concentration for bound paclitaxel |
0.281 μM |
k
dissoc, rate constant of paclitaxel dissociation from cells |
0.462/h |
k
assoc, rate constant of paclitaxel association with cells |
1.64/μM/h |