Table I.

Values of Model Parameters

From literature reports (references in parenthesis)
K, hydraulic conductivity of tumor tissue in periphery	2.5 × 10−7 cm2/mmHg/s (39)
L p, hydraulic conductivity of vessel wall	1.86 × 10−6 cm/mmHg/s (39)
S v/V, vessel surface area/unit tissue volume in tumor periphery	200 cm2/cm3 (37)
P d, permeability of vessel wall to paclitaxel	2.0 × 10−5 cm/s (68)
P v, microvascular hydrostatic pressure	3.0 mmHg (43)
P ip, pressure in intraperitoneal cavity	−0.2 mmHg (57)
πi, osmotic pressure of interstitial proteins	19.8 mmHg (39)
πv, osmotic pressure of plasma proteins	17.3 mmHg (39)
Calculated
D int, drug diffusion coefficient in tumor interstitium	0.77 × 10−6 cm2/s
D′0, drug diffusion coefficient in tumor periphery	0.27 × 10−6 cm2/s
σ v, reflection coefficient of vessels for plasma protein	0.0012
σ p, reflection coefficient of vessels for paclitaxel	2.5 × 10−5
Experimentally determined
A, intercept of distribution phase in C ip,total vs. time plot	415 μM
B, intercept of elimination phase in C ip,total vs. time plot	7.34 μM
A′, intercept of distribution phase in C plasma,total vs. time plot	7.18 μM
B′, intercept of elimination phase in C plasma,total vs. time plot	0.35 μM
α ip, rate constant of distribution phase in C ip,total vs. time plot	0.41/h
β ip, rate constant of elimination phase in C ip,total vs. time plot	0.16/h
α p, rate constant of distribution phase for C plasma,total vs. time plot	0.67/h
β p, rate constant of elimination phase for C plasma,total vs. time plot	0.09/h
k p, rate constant for drug absorption into blood	0.95/h
B max, maximum cell binding capacity for paclitaxel	81.8 μM
k d, equilibrium concentration for bound paclitaxel	0.281 μM
k dissoc, rate constant of paclitaxel dissociation from cells	0.462/h
k assoc, rate constant of paclitaxel association with cells	1.64/μM/h