Table IV.
C max (μg/mL)a | t max (h)a | AUC0–8 h (μg h/mL) | AUC0-72h (μg h/mL) | Rel. BA (%) | |
---|---|---|---|---|---|
SNEDDS | 0.9 (0.2–1.8) | 8.0 (0.5–30) | 4.1 ± 3.7 | 25.7 ± 15.5 | 116.7 ± 51.2 |
Super-SNEDDS | 1.0 (0.1–2.7) | 8.0 (1–30) | 6.4 ± 6.6 | 26.1 ± 12.3 | 114.9 ± 63.6 |
SNEDDS suspension | 1.3 (0.4–2.2) | 8.0 (1–30) | 6.3 ± 4.0 | 26.4 ± 9.0 | 158.2 ± 139.5 |
Lipanthyl | 0.9 (0.4–1.2) | 24 (8–72) | 1.9 ± 2.3 | 23.7 ± 7.5 | 100 |
SNEDDS self-nanoemulsifying drug delivery systems, C max peak plasma concentrations, t max time of occurrence, AUC areas under the plasma concentration-time curves
aMedian and range in brackets