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. 2014 Apr 29;14:73. doi: 10.1186/1471-2466-14-73

Table 4.

Peak and late inspiratory and expiratory flow of the lung (PIF, LIF, PEF, LEF) during different parts of the respiratory cycle in different regions-of-interest (ROI)

PIF
 Phase 1
 Inspiration
  
 Global ROI
 Ventral ROI $/§
Middle ROI
 Dorsal ROI
PEEP [mbar] V T /weight [ml/kg] Lung n Mean ± sd [ml/s] Mean ± sd [ml/s] Mean ± sd [ml/s] Mean ± sd [ml/s]
0
 15
 healthy
 7
 467.27 ± 56.69
 109.87 ± 15.45
 317.60 ± 34.38
 298.54 ± 120.62
0
 20
 healthy
 7
 571.94 ± 100.47
 126.10 ± 17.69
 345.79 ± 54.36
 327.13 ± 127.57
5
 15
 healthy
 7
 510.92 ± 102.16
 116.04 ± 14.20
 324.25 ± 73.59
 334.11 ± 135.32
5
 20
 healthy
 7
 621.80 ± 85.20
 129.70 ± 16.65
 396.75 ± 50.78
 348.89 ± 139.71
10
 15
 healthy
 7
 550.89 ± 82.35
 105.82 ± 13.13
 335.46 ± 48.16
 339.63 ± 132.18
10
 20
 healthy
 7
 711.67 ± 104.68
 123.85 ± 22.84
 424.07 ± 84.16
 402.98 ± 143.06
5
 15
 healthy
 6
 901.90 ± 92.06
 118.94 ± 32.59
 512.73 ± 81.67
 283.00 ± 59.44
5
 15
 LAV
 6
 968.55 ± 64.49
 158.94* ± 24.26
 602.78* ± 91.51
 335.89 ± 83.67
LIF
 Phase 2
 Inspiration
  
 Global ROI
 Ventral ROI $
Middle ROI
 Dorsal ROI
PEEP [mbar]
 V T /weight [ml/kg]
 Lung
 n
 Mean ± sd [ml/s]
 Mean ± sd [ml/s]
 Mean ± sd [ml/s]
 Mean ± sd [ml/s]
0
 15
 healthy
 7
 72.04 ± 16.52
 10.26 ± 5.27
 36.77 ± 28.00
 19.03 ± 4.99
0
 20
 healthy
 7
 86.66 ± 36.51
 10.80 ± 4.08
 43.22 ± 24.84
 17.66 ± 4.93
5
 15
 healthy
 7
 55.58 ± 23.32
 5.65 ± 4.35
 18.02 ± 3.12
 16.05 ± 4.31
5
 20
 healthy
 7
 52.11 ± 10.05
 9.50 ± 4.76
 27.59 ± 15.06
 10.45 ± 5.20
10
 15
 healthy
 7
 47.17 ± 16.57
 7.83 ± 3.67
 23.31 ± 8.22
 11.93 ± 9.44
10
 20
 healthy
 7
 64.37 ± 45.81
 8.69 ± 4.00
 32.91 ± 5.27
 18.07 ± 15.34
5
 15
 healthy
 6
 13.58 ± 2.70
 4.03 ± 0.52
 18.55 ± 8.65
 12.72 ± 5.84
5
 15
 LAV
 6
 19.09* ± 5.14
 2.82 ± 1.83
 10.74* ± 5.29
 13.02 ± 3.73
PEF
 Phase 3
 Expiration
  
 Global ROI
 Ventral ROI $/§
Middle ROI
 Dorsal ROI
PEEP [mbar]
 V T / weight [ml/kg]
 Lung
 n
 Meann ± msd [ml/s]
 Mean ± sd [ml/s]
 Mean ± sd [ml/s]
 Mean ± sd [ml/s]
0
 15
 healthy
 7
 -587.38 ± 86.73
 -130.15 ± 21.79
 -360.79 ± 60.67
 -344.81 ± 140.78
0
 20
 healthy
 7
 -687.01 ± 138.84
 -141.14 ± 24.29
 -419.64 ± 68.85
 -360.89 ± 135.22
5
 15
 healthy
 7
 -609.64 ± 164.78
 -122.24 ± 16.87
 -359.02 ± 71.82
 -351.49 ± 156.67
5
 20
 healthy
 7
 -675.96 ± 142.03
 -119.51 ± 20.03
 -397.41 ± 67.45
 -413.33 ± 170.68
10
 15
 healthy
 7
 -581.72 ± 119.23
 -107.19 ± 13.15
 -356.31 ± 53.46
 -353.22 ± 127.59
10
 20
 healthy
 7
 -685.25 ± 114.72
 -108.40 ± 13.30
 -395.27 ± 41.11
 -383.60 ± 152.15
5
 15
 healthy
 6
 -666.61 ± 62.94
 -94.05 ± 12.91
 -373.52 ± 74.09
 -257.96 ± 47.51
5
 15
 LAV
 6
 -734.43* ± 44.74
 -130.40* ± 26.63
 -441.15 ± 102.11
 -349.22 ± 145.95
LEF
 Phase 4
 Expiration
  
 Global ROI
 Ventral ROI $
Middle ROI §
Dorsal ROI
PEEP [mbar]
 V T / weight [ml/kg]
 Lung
 n
 Mean ± sd [ml/s]
 Mean ± sd [ml/s]
 Mean ± sd [ml/s]
 Mean ± sd [ml/s]
0
 15
 healthy
 7
 -40.23 ± 25.65
 -5.74 ± 4.36
 -27.25 ± 14.37
 -7.11 ± 5.85
0
 20
 healthy
 7
 -58.85 ± 30.50
 -8.73 ± 4.94
 -48.72 ± 19.19
 -16.04 ± 7.86
5
 15
 healthy
 7
 -50.20 ± 17.22
 -5.41 ± 4.37
 -27.87 ± 8.07
 -3.74 ± 1.78
5
 20
 healthy
 7
 -62.46 ± 37.63
 -5.46 ± 2.57
 -47.50 ± 13.66
 -16.79 ± 10.81
10
 15
 healthy
 7
 -49.84 ± 37.89
 -3.77 ± 2.04
 -23.78 ± 22.54
 -9.10 ± 11.72
10
 20
 healthy
 7
 -86.42 ± 27.98
 -6.67 ± 3.74
 -51.34 ± 15.72
 -15.81 ± 5.00
5
 15
 healthy
 6
 -39.16 ± 23.89
 -5.71 ± 3.26
 -26.44 ± 10.16
 -8.36 ± 4.09
5 15 LAV 6 -36.15 ± 27.84 -6.29 ± 2.20 -20.37 ± 16.26 -2.63* ± 1.00

PEEP: positive end-expiratory pressure. VT/weight: tidal volume per body weight. sd: standard deviation. LAV: lavage injury. Statistical analysis (two-way ANOVA): *p <0.05: comparison to condition above. ROI analysis: $p < 0.05 comparison to middle ROI, §p < 0.05 comparison to dorsal ROI.