Table 2.
Associations between the G1790A polymorphism and cancer risk
| Varibles |
AA + AG VS GG |
AA VS AG + GG |
AA VS GG |
AG VS GG |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n a | OR (95% CI) | P b | n a | OR (95% CI) | P b | n a | OR (95% CI) | P b | n a | OR (95% CI) | P b | |
|
Overall |
25 |
1.85 (1.27-2.69 ) |
0 |
26 |
5.69 (3.87-8.37) |
0 |
12 |
6.63 (4.49-9.79) |
0 |
11 |
2.39 (1.53-3.75) |
0 |
|
Overall for HWE
c
|
22 |
1.82 (1.27-2.59) |
0 |
10 |
7.01 (4.42-11.09) |
0 |
10 |
7.75 (4.87-12.34) |
0 |
10 |
3.4 (2–5.8) |
0 |
|
cancer cite |
|
|
|
|
|
|
|
|
|
|
|
|
|
Prostate cancer |
3 |
1.41 (0.93-2.14) |
0.1 |
1 |
3.24 (0.13-79.9) |
0.47 |
1 |
3.34 (0.13-82.30) |
0.46 |
1 |
1.98 (0.07-50.4) |
0.67 |
|
Head and neck cancer |
6 |
3.57 (0.98-12.99) |
0.05 |
3 |
58 (1.75-1924.88) |
0.02 |
3 |
101.38 (22.09-65.29) |
0 |
3 |
12.53 (2.42-64.76) |
0 |
|
Pancreatic cancer |
2 |
2.5 ( 0.93-6.72) |
0.06 |
1 |
18.8 (0.96-371.55) |
0.05 |
1 |
18.3 (0.93-360.19) |
0.05 |
1 |
29.4 (1.12-772.37) |
0.04 |
|
Lung cancer |
3 |
2.14 ( 1.56-2.95) |
0 |
2 |
4.5 (2.3-8.81) |
0 |
2 |
5.42 (2.74-10.7) |
0 |
2 |
3.02 (1.48-6.16) |
0 |
|
Renal cell carcinoma |
3 |
0.94 ( 0.16-5.29) |
0.95 |
2 |
2.69 (1.20-6.03) |
0.01 |
2 |
3.71 (1.72-7.99) |
0.46 |
1 |
0.81 (0.33-2) |
0.65 |
|
Other cancer |
5 |
2.11 ( 1.03-4.32) |
0.45 |
1 |
0.35 (0.01-8.80) |
0.53 |
1 |
0.35 (0.01-8.8) |
0.52 |
1 |
0.36 (0.01-9.68) |
0.54 |
|
Breast cancer |
3 |
0.63 ( 0.19-2.08) |
0 |
2 |
1.44 (0.34-6.08) |
0.62 |
2 |
1.43 (0.37-5.44) |
0.59 |
2 |
1.45 (0.34-6.17) |
0.61 |
|
Subgroup by ethnicity |
|
|
|
|
|
|
|
|
|
|
|
|
|
Asian |
13 |
1.75 (1.3-2.37) |
0 |
7 |
3.37 (1.94-5.86) |
0 |
7 |
3.82 (2.19-6.66) |
0 |
7 |
2.41 (1.31-4.43) |
0 |
|
Caucasian |
9 |
1.12 (0.41-3.03) |
0.81 |
4 |
3.74 (1.85-7.54) |
0 |
4 |
5.05 (2.53-10.07) |
0 |
3 |
2.66 (0.33-21.23) |
0.35 |
|
control source |
|
|
|
|
|
|
|
|
|
|
|
|
|
PB |
22 |
1.95 (1.33-2.85) |
0 |
11 |
5.9 (4.0-8.8) |
0 |
11 |
7.2 (4.79-10.82) |
0 |
11 |
2.39 (1.53-3.75) |
0 |
|
HB |
3 |
0.39 (0.01-9.90) |
0.56 |
1 |
0.88 (0.04-16.82) c |
0.93 |
1 |
0.44 (0.02-8.53) |
0.59 |
0 |
No statistics |
|
|
Gender |
|
|
|
|
|
|
|
|
|
|
|
|
|
Female |
5 |
0.92 (0.46-1.84) |
0.82 |
3 |
1.11 (0.34-3.66) |
0.85 |
3 |
1.13 (0.34-3.7) |
0.83 |
3 |
1.13 (0.31-4.02) |
0.84 |
| Male | 3 | 1.41 (0.93-2.14) | 0.1 | 1 | 3.24 (0.13-79.9) | 0.47 | 1 | 3.34 (0.13-82.3) | 0.46 | 1 | 1.98 (0.07-50.4) | 0.67 |
aNumber of comparisons.
bP value of Q-test for heterogeneity test.
cData after excluding those studies’ controls not in Hardy-Weinberg equilibrium.