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. 2014 Apr;19(100):25–33. doi: 10.1016/j.cbpa.2013.12.010

Table 1.

A selection of recent examples of engineering of aldolases for use as biocatalysts

Enzyme Reactions Ref.
2-Deoxyribose-5-phosphate aldolase Natural [19]
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Engineered
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2-Keto-3-deoxy-6-phosphogluconate aldolase Natural [20••,21]
graphic file with name fx3.gif



Engineered
graphic file with name fx4.gif



Rhamnulose-1-phosphate aldolase Natural [26]
graphic file with name fx5.gif



Engineered
graphic file with name fx6.gif



Fructose-6-phosphate aldolase Natural [29,30]
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Engineered
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Transaldolase Natural [31,32]
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Engineered
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4-Oxocrotonate tautomerase Natural [34]
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Engineered
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BphI Natural [42,47]
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Engineered
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2-Keto-3-deoxygluconate aldolase Natural [43••]
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Engineered [43••]
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Engineered increased stability at lower temperatures