Table 2.
List of UPR genes alternative names and function.
| UPR gene | Full and alternative names | Transcription control | Function |
|---|---|---|---|
| SYVN1 | Synovial apoptosis inhibitor 1 | sXBP1, ?ATF6 |
ERAD, E3ligase |
| TXNDC4 | ERP44 (ER protein 44) | sXBP1 | Chaperone Disulfide bond formation Cell redox homeostasis |
| PDIA4 (ERP70/72) | Protein disulfide isomerase family A, member 4 | sXBP1 | Cell redox homeostasis |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | sXBP1 | Heat shock protein Protein folding |
| HERPUD2 | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain family member 2 | ATF4 ATF6 |
Co-chaperone |
| BIP (HSPA5) | Immunoglobulin heavy chain-binding protein (Heat shock 70 kDa protein 5) |
ATF4 ATF6 |
Chaperone |
| GADD34 (PPP1R15A) | Growth arrest and DNA damage-inducible protein (Protein phosphatase 1, regulatory (inhibitor) subunit 15A) |
ATF4 ATF6 |
Apoptosis Cell cycle arrest Regulation of translation Response to DNA damage |
| CHOP (DDIT3) | C/EBP-homologous protein (DNA-damage-inducible transcript 3) | ATF4 ATF6 |
Transcription regulation Growth arrest Apoptosis |
| IRE1 (ERN1) | Inositol-requiring protein 1 (Endoplasmic reticulum to nucleus signalling 1) |
? | sXBP1 activation Apoptosis UPR |