Fig. 2.

Perturbed peripheral B-cell maturation in WAS patients. A. Absolute counts of CD19⁺ cells of WAS patients (black dots) and age-matched HDs (white dots) were analyzed when available. B. Representative plots of flow cytometric analysis of blood B-cell subsets of a HD and a WAS patient (age range: <3y) are shown. C. Graphs display frequencies of the four main B-cell subsets in the blood of WAS patients and age-matched HDs. Individual data points are displayed with mean and SD. Groups are compared to controls and significant values are indicated: ***P ≤ 0.0005; **P < 0.005; *P < 0.05. (HD < 3y, n = 29; HD 3–12y, n = 27).