Fig. 5.

Alterations in the memory B-cell compartment of WAS patients. Graphs indicate the frequencies of: IgM-only B cells (left) and CD27⁻IgG⁺ B cells (right), representing memory B cells firstly involved in a GC response (A); switched memory B cells identified as CD27⁺IgG⁺ (left) and CD27⁺IgA⁺ (right) B cells (B); GC-independent memory B cells (C). Significant values compared to normal controls are indicated. ***P ≤ 0.0005; **P < 0.005; *P < 0.05.