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. 2014 Apr 30;4:88. doi: 10.3389/fonc.2014.00088

Figure 2.

Figure 2

Fibroblasts induce STAT1 signaling in tumor cells. (A) HCT116 cells transfected with GAS-LUC were treated as indicated, (B) HCT116 and Hke-3 cells were transfected with GAS-LUC and were co-cultured with 18Co cells, fibroblasts isolated from a normal donor (HIF ND), a patient with ulcerative colitis (HIF UC) or Crohn’s disease (CD). (C) HCT116 and Hke-3 cells were co-cultured with 18Co, HIF, or CD myofibroblasts and the levels of pSTAT1 and IRF1 were determined by immunoblotting. *p = < 0.05 versus control cells; NS, non-significant; #p < 0.02; **p < 0.01 versus 18Co and HIF ND fibroblasts.