Table 1.
Behavioral results of heterozygous BDNF-KO mice.
| Behavioral tests | Result | Background | Reference |
|---|---|---|---|
| BW, LA and FI | Increased appetite and weight, and decreased locomotor activity in BDNF(±) mice, but not in heterozygous NT4/5, NT3, TrkC, or TrkA knockout mice | C57Bl/6 and 129Sv mixed F2 background | Kernie et al., 2000 |
| Anhedonia, EPM, FST, LH, NOR, OF, PA, SP, staircase | No differences in most of tests. Longer escape latencies in LH | C57Bl/6 and 129Sv mixed background | MacQueen et al., 2001 |
| NSF, OF, RI, TST | No behavioral changes, effects of ADs blocked in heterozygous mice | C57Bl/6 and 129Sv mixed background | Ibarguen-Vargas et al., 2009 |
| EZM, FC, FST, LD, novel cage, OF, RR | No behavioral changes | C57Bl/6 and 129Sv mixed background | Chourbaji et al., 2004 |
| EPM, OF | Increased sensitivity to pre/postnatal maternal environment (high or low maternal care) | C57Bl/6J and/or BALB/c | Carola and Gross, 2010 |
| BW, FI, OF, RI | Increased appetite, weight and aggressiveness | C57Bl/6 | Lyons et al., 1999 |
| BW, EPM, FC, LA, NSF, OF, RI | Increased weight, aggressiveness, and anxiety-like behavior, impaired contextual but intact cue memory. No changes in locomotor activity | C57Bl/6J | Chen et al., 2006 |
| FST | No behavioral changes, effects of ADs blocked in heterozygous mice | 129Sv X BALB/c | Saarelainen et al., 2003 |
| FC, pain, vision and auditory tests | No changes in senses or baseline freezing, impairment in contextual memory-, but not in cue memory test | C57Bl/6 | Liu et al., 2004 |
| FC, OF | No changes in locomotor activity, but adult animals have impaired fear extinction learning | C57Bl/6J | Psotta et al., 2013 |
| Spontaneus olfactory discrimination | Impairment in olfactory system | C57Bl/6 | Bath et al., 2008 |
| FST | Depression-like behavior after stress or MEK inhibitor | C57Bl/6? | Duman et al., 2007 |
| EPM, OF | Increased anxiety-like behavior, no changes in locomotor activity | C57Bl/6 | Li et al., 2010 |
| ASR, BW, FC, OF, RR, WM | No behavioral changes, increased weight | C57Bl/6 | Uutela et al., 2012 |
| WM | Impaired learning and memory | 129/J x BALB/c | Linnarsson et al., 1997 |
| FST, OF | No behavioral changes, effects of ADs blocked in heterozygous mice | C57Bl/6J | Lindholm et al., 2012 |
Abbreviations: ASR, Acustic startle response; BW, Body weight; EPM, elevated plus-maze; FC, fear conditioning; FI, food intake; FST, forced swimming test; EZM, elevated zero maze; LA, locomotor activity; LD, light-dark box; LH, learned helplessness; NOR, novel object recognition; NSF, novelty suppressed feeding; OF, open field; PA, passive avoidance; RI, resident-intruder test; RR, RotaRod; SP, sucrose preference; TST, tail suspension test; WM, water maze.