Table 3.
Behavioral results of transgenic TrkB mice.
| Mutant mice | Behavioral tests | Result | Background | Reference |
|---|---|---|---|---|
| Forebrain-specific TrkB-receptor Knockout | EM, EZM, FST, NOR, OF | Increased locomotor activity in OF and mobility in FST. No changes in anxiety-like behavior | C57Bl/6N × 129/sv × CBA/J | Zörner et al., 2003 |
| TrkB(±) | Spontaneus olfactory discrimination | Impairment in olfactory system | C57Bl/6 | Bath et al., 2008 |
| TrkB(±) | Circadian rythm | Disrupted circadian rythm | C57Bl/6 | Allen et al., 2005 |
| TrkB-KO in adult born neurons | EPM, OF | Decreased locomotor activity, increased anxiety-like behavior | C57Bl/6 | Bergami et al., 2008 |
| TrkB-KO in adult born neurons | NSF, TST | No behavioral changes, effects of ADs blocked | C57Bl/6 | Li et al., 2008 |
| Overexpressing catalytic TrkB receptor (TrkB.TK+), used as heterozygous | FST | Antidepressant-like behavior | CD2F1 (BALB/c × DBA/2) | Koponen et al., 2005 |
| Overexpressing catalytic TrkB receptor (TrkB.TK+), used as heterozygous | CTA, EPM, FC, HP, LD, OF, RR, WM, Y-maze | Anxiolytic-like behavior, enhanced contextual and associative learning and memory. No changes in locomotor activity or coordination | CD2F1 (BALB/c × DBA/2) | Koponen et al., 2004 |
| Overexpressing catalytic TrkB receptor (TrkB.TK+), used as heterozygous | OF, WM | Normal contextual learning and memory. Increased locomotor activity in male, but not in female mice | C57Bl/6 | Kemppainen et al., 2012 |
| Overexpressing truncated TrkB receptor (TrkB.T1, dominant negative), used as heterozygous | FST | No behavioral changes, effects of ADs blocked in heterozygous mice | CD2F1 (BALB/c × DBA/2) | Saarelainen et al., 2003 |
| Overexpressing truncated TrkB receptor (TrkB.T1, dominant negative), used as heterozygous | WM | Impairment in contextual learning and memory | CD2F1 (BALB/c × DBA/2) | Saarelainen et al., 2000 |
| Overexpressing truncated TrkB receptor (TrkB.T1, dominant negative), used as heterozygous | OF, WM | Normal contextual learning and memory | C57Bl/6 | Kemppainen et al., 2012 |
| Overexpressing truncated TrkB receptor (TrkB.T1, dominant negative), used as heterozygous | BW, SA | Normal social behavior; stress induces social avoidance. Normal body weight | C57Bl/6 | Razzoli et al., 2011 |
| TrkBF616A, time controlled inhibition of TrkB receptor | FC | Inhibition of TrkB receptor prior to testing prevents formation of fear conditioning | C57Bl/6 | Johnson et al., 2008 |
| TrkBF616A, time controlled inhibition of TrkB receptor | Inhibition of TrkB receptor prevents status epilepticus | C57Bl/6 | Liu et al., 2013 |
Abbreviations: BW, body weight; CTA, conditioned taste aversion; EM, emergency test; EPM, elevated plus-maze; EZM, elevated zero maze; FC, fear conditioning; FST, forced swimming test; HP, hotplate; LD, light-dark box; NOR, novel object recognition; NSF, novelty suppressed feeding; OF, open field; RR, rotarod; SA, social avoidance; WM, water maze.