Figure 1. Cartoon illustration of creating genomic neighborhoods. First, the mAdd known targets to complete the downstream signaling networkaster regulator (MR) is added along with its predicted target genes (green arrows). Second, known targets of the master regulator are added. Third, to complete the downstream signaling network, genes are hierarchically added according to regulatory relationships. Fourth, direct and indirect regulators of the master regulator are added. Non-differentially expressed genes (red) are removed after each step.