Table 3.
Author | Nature of study | Age at FAP diaqnosis/vears | Operatio technique | Interval, surgery to adenoma/vears | Age at adenoma diagnosis | Number of patients operated, followed and studied (n=1412) | Number of patients developed adenomas (n=515, (36%) | Location | Histology |
---|---|---|---|---|---|---|---|---|---|
Hamilton, 197929 | Prospective series | IRA | 2 and 26 | Not reported | 9 | Pouch mucosa and ARS | Adenomas | ||
Beart, 198233 | Case report | 22 | KP | 16 | 48 | 1 | 1 | Kock continent ileostomy | Tubulovillous adenoma |
Wolfstein, 198294 | Retrospective | IAA | 3 | 2 | 2 | Rectal mucosa | Adenomas 8 and 12 cm | ||
Jarvinen, 198395 | Retrospective | IRA | Not reported | 5 | 1 | ARS | Adenomas | ||
Burt,198496 | Retrospective | IRA | 11 | 6 | ARS | Adenomas | |||
Shepherd, 198719 | Retrospective | RPC | 1 | 12 | 2 | Pouch mucosa | Adenomas (LGD) | ||
Stryker, 198737 | Case report | KP | 12 | 33 | 1 | 1 | Reservoir adenomas | Tubulovillous adenomas | |
Myrhoj, 198923 | Case report | IAA | 25 | 12 | 1 | 1 | IAA | Adenomas to 12 cm (LGD) | |
Nugent, 199262 | Retrospective | 26 | IRA | 30 | 56 | 222 | 5 | Pouch mucosa | Adenomas (LGD) |
Nugent, 199330 | Retrospective | RPC | 0.1, 0.25 and 1 | Mean 28 (range, 12–65) | 50 | 38 | Pouch mucosa | Adenomas | |
Bertoni, 199528 | Retrospective | IRA | Not reported | 17 | 9 | ARS | Adenomas | ||
Church, 199631 | Case report | RPC | Not reported | 1 | 1 | Pelvic pouch mucosa | Adenomas | ||
Wu, 199879 | Retrospective | RPC | Not reported | 26 | 11 | Pouch mucosa, gut above pouch & ATZ | Adenomas | ||
Van Duijvendijk, 199973 | Retrospective | Not reported | RPC (6 mucosectomized & 7 stapled anastomoses | 38 (range 22–60) | Median, 35(16–60) | 126 | 13 | Anastomotic site | Adenomas, 4 moderate dysplasia, 4 mild dysplasia and 4 severe dysplasia |
Valle, 200197 | Retrospective | RPC | 5 | Not reported | 1 | 1 | Diffuse | Adenomas | |
Thompson-Fawcett, 200120 | Retrospective | 5 KP, 28 RPC | 7 | 33 | 21 | Pouch mucosa | Adenomas 1 to 3 mm | ||
Pare, 200121 | Retrospective | RPC initial procedure, in 19 converted IRA to a RPC | Mean ± SDE, 7.1 ± 4.5) | 27 (range,9–67; mean ± SDE, 28±12) | 85 | 30 | Pouch mucosa | Adenomas (in 28 grossly vissible (one HGD, 21 LGD) <->5mm,and in 2 microadenomas) | |
Polese, 200398 | Retrospective series | Not reported | RPC | 0.3 to 12 | 9 and 11 | 46 (9 handsewn / 37 stapled IPAA) | 2 | Pouch mucosa & at the margin | Adenomas |
Beveridge, 200432 | Case report | Median 35 (range, 32–38) | RPC | 4 and 10 | 32 and 38 | 2 | 2 | Lower pouch 2 cm of terminal cuff - behind a fold in the upper pouch. Terminal ileum & rectal glandular mucosa from incomplete MU | Adenoma 3 cm × 2 cm & 2 cm × 2 cm large. Tubulovillous adenomas Microadenomas |
Groves, 200522 | Retrospective | Median, 25 (range, 13 to 45) | IRA | Mean 12 (range 0 to 39) | 18 to 65 | 30 IPAA and 30 conversional IRA | 34 | ARS | Adenomas (5 patients had > 1 cm) |
Von Roon, 200774 and 201125 | Retrospective and Retrospective | Mean, 32.6±10.8 and 32.6±11.9 (range 17–63) | RPC (121(64%) were hand- sewn and 54 (29%) stapled)). W-pouch, n=57; J-pouch, 102; and S-pouch, n=10) and RPC + MUC |
Mean 10.4 (mucosectomy group) and 7.2 (stapled group) and 7,7,8, 12, 13, 11, 11, 12, 23&13 | Mean 10 (range, 2 to 23) and 28.7±12 (mean±SD) | 91 of 189 and 189 of 189 (out of 1,652) | 24 and 96 | Handsewn vs. stapled (19% vs. 38%; p= 0.047) | Adenomas and adenomas (9 patients had > 10 mm) Adenomas: 18/23 (78%)(1 HGD & 16 LGD) |
Moussata, 200853 | Retrospective | 42.6±11.7 (mean±SD) | IPAA (23) IRA(n=21) |
4.7 ±3.3 (mean ±SD) 16.4 (mean ± SD) |
28.7±12 (mean±SD) | 44 | 18 10 |
Pouch mucosa ARS |
Adenomas: 16/21 (77%)(2 HGD & 8 LGD) & lymphoid nodular hyperplasis in 6 |
Tonellie, 201217 | Prospective | 32.6±11.9 (range 17–63) | RPC+MUC(51); IRA (18, later RPC) | 11 (range 1–24). Mean endoscopic session was 9, range, 3–22 | the number of adenomas ranged 1–47 per patient | 69 | 25 | All adenomas found in Pouch-body mucosa | Adenomas |
Pommaret, 201382 | Retrospective | Not reported | IPAA 118, IRA 13, 8 DI | Median 15 | 25 (range, 9–61) | 139 | 85 | Pouch mucosa, ARS, afferent ileal loop, DI | Adenomas (7 HGD) |
Wasmuth, 201349 | Retrospective | Mean 20 (range, 10–49) | IPAA (61); IPAA+MUC (39); IPAA-MUC (22) (15 stapled and 7 handsewn)) | MUC and without MUC Mean 15.5 and 13.7 |
15.5 for mucosectomy and 13.7 for without mucosectomy | 61 | 28 | Anastomotic site | Adenomas and in 1 patient without mucosectomy had cancer (Dukes A) |
Boostrom, 201365 | Retrospective | Median, 26 (range, 4–60) | RPC(J-pouch, n=104; Kock pouch, n=9; S-pouch, n=3 & W-pouch, n=1) | Range, 11–59 | Median, 11 (range, 2–35.3) | 117 | 39 | 14 pouch, 2 pre-pouch ileum, 3 anastomotic site, 1 Kock nipple valve, 6 pouch and anastomosis, 2 pouch and pre-pouch ileum and 9 not described. | Tubular adenoma (n=22) and tubulovillous adenoma (n=8). Low-grade-dysplasia (n=30), non-dysplastic (n=2) and adenocarcinoma (n=1) |
Abbreviations:
HGD = High-grade dysplasia, LGD = Low-grade dysplasia, ARS= Anorectal segment, IRA = lleorectal anastomosis, RPC = Restorative proctocolectomy, IPAA = ileal pouch-anal anastomosis, MUC = Mucosectomy, IPAA+MUC = ileal pouch-anal anastomosis with mucosectomy; IPAA-MUC = ileal pouch-anal anastomosis without mucosectomy; ARS = Anorectal segment, DI=Definite ileostomy.