Table 4.
Multivariate analysis of the risk of adenoma formation in the anorectal segment. Stapled IAA and age at RPC > 40 years were independent predictors of adenoma formation in ARS. There was no significant association between the APC mutation position or preoperative colonic polyp density and adenoma risk. Reproduced with permission of the publisher: Weston-Petrides et al., Arch Surg 2008;143:406–412.52
| Preoperative Factors | Hazard Ratio | 95% Confidence Interval | P < |
|---|---|---|---|
| Gender | |||
| Female | 1 | ||
| Male | 0.80 | 0.47–1.43 | 0.820 |
|
| |||
| Age at restorative proctocolectomy, years | |||
| <20 | 1 | ||
| 21–39 | 1.31 | 0.67–2.56 | 0.426 |
| ≥40 | 2.20 | 1.01–4.89 | 0.049 |
|
| |||
| Ileoanal anastomosis | |||
| Handsewn and mucosectomy | 1 | ||
| Stapled | 3.45 | 1.87–6.39 | <0.001 |
|
| |||
| APC mutation (codon) | |||
| 1309 | 1 | ||
| <1250 | 1.96 | 0.79–4.82 | 0.079 |
| 1250–1464 (excluding 1309) | 0.34 | 0.07–1.72 | 0.194 |
| >1464 | 1.49 | 0.18–12.53 | 0.289 |
|
| |||
| Preoperative colonic polyposis density | |||
| <1000 | 1 | ||
| 1000–4999 | 1.07 | 0.55–2.10 | 0.837 |
| >5000 | 0.94 | 0.27–3.24 | 0.925 |