Table 5.

Summary of available data on the incidence of adenomas in the ARS in mucosectomized, handsewn IPAA and stapled IPAA in patients surgically treated for FAP.

Incidence of Adenoma in the ARS in mucosectomized, Handsewn IPAA and Stapled IPAA in Patients operated for FAP
Author	Follow-up-yrs	Number of patients followed-up in the study	Number of patients developed neoplastic transformation	IPAA with mucosectomy that developed neoplastic transformation	IRA Stapled that developed neoplastic transformation	P-value
Van Duijvendijk et al, 1999⁷³	Median 5.5, range1–1.7)	126	13	Handsewn with mucosectom: 6 (of 13) (46%)) vs. Double-stapled without mucosectomy: 7 of 13) (54%))	N/A	0.01
Remzietal. 2001²⁴	5.8 vs. 3.6	119	44 (58%)	9 (of 42) (21%)) in the pouch and 6 of 42 had it in mucosectomized ARS	21 (of 76) (28%)) in ARS and 8 (11%) had adenomas in the pouch body mucosa	N/A
Moussata et al.⁵³	IPAA (4.76±3.3) IRA(16.4±8.5)	44	24 (55%)			0.0001
Friederich et al. 2008⁹³	6.8 (range 0.4–20.3)	212	74 (35%)	29%	64%	0.0004
Von Roon et al, 2007⁷⁴ and 2011²⁵	5 (range 0.1–24.75) and 10.3 (median)	(91 and 49 =)140	24 (26%) and 52 (37%)	11 (19%) Handswen vs. stapled anastomosis (19 vs. 38%) and 22.6%	13 (38)% and 51.1%	0.047 and 0.001
Pommaret et al, 2013⁸²	Median 15	139	85 (65%)	73 of 118 (62%) patients had adenomas in pouch mucosa, 57 (48.3%) had advanced adenomas in 15 patients (12.7%). Transformation of IRA to IPAA was done for 36 patients). In 8 cases (16.3%) to treat rectal cancer	12 of 13 (92.3%) had rectal adenomas, including one patient with advanced rectal rectal adenoma, treated by endoscopic mucosal resection	0.0001
Wasmuth et al, 2013⁴⁹	20 (range, 10–49)	61	18(30%)	Mucosectomized: 4 (of 39) (10%)) vs. None-mucosectomized: 14 (of 22) (64%))	N/A	The estimated rates was 17% vs. 75%. 0.0001
Boostrom et al.⁶⁵	Median 26 (range, 4–16)	117	39 (33%)	Handsewn with mucosectomy (31) (26%) vs. Stapled without mucosectomy (8) (7%)	N/A	N/A