Table 2. Life stress and NR3C1 methylation scores by amplicons.

	NR3C1_1			NR3C1_2			NR3C1_3
	B	s.e.	P	B	s.e.	P	B	s.e.	P
Perinatal stress	0.03	0.02	0.14	−0.01	0.02	0.78	0.01	0.02	0.53
Traumatic youth experiencesa
Sexual abuse
Single exposure	0.37	0.09	<0.0001	0.44	0.12	<0.001	−0.08	0.10	0.40
Repeated exposure	0.50	0.12	<0.0001	0.13	0.17	0.45	−0.26	0.13	0.05
Physical abuse
Single exposure	0.01	0.04	0.73	0.02	0.06	0.68	−0.02	0.05	0.66
Repeated exposure	0.49	0.12	<0.0001	−0.09	0.15	0.56	−0.18	0.12	0.15
Other trauma
Single exposure	0.09	0.05	0.06	−0.04	0.07	0.52	−0.10	0.06	0.08
Repeated exposure	0.53	0.08	<0.0001	0.07	0.11	0.56	−0.26	0.09	<0.01
SLEsb
Total (0–15 years)	0.05	0.02	0.02	0.03	0.03	0.25	−0.03	0.02	0.20
Childhood (0–11 years)	0.01	0.02	0.57	0.00	0.03	0.97	−0.03	0.02	0.22
Adolescence (12–15 years)	0.05	0.02	<0.01	0.04	0.03	0.13	−0.01	0.02	0.62

Abbreviations: B, regression coefficient; SLEs, stressful life events.

Linear regression of early-life stress and multivariate regression analyses of SLEs in two age categories on NR3C1 methylation scores. Bold numbers indicate significant results (P<0.05).

^aNo exposure is the reference category.

^bZ-scores.