Table 3. Life stress and NR3C1 methylation scores of the three highest methylated CpG units.

	NR3C1_1CpGU12			NR3C1_2CpGU13			NR3C1_2CpGU14
	B	s.e.	P	B	s.e.	P	B	s.e.	P
Perinatal stress	0.05	0.11	0.64	0.05	0.20	0.81	−0.05	0.09	0.58
Traumatic youth experiencesa
Sexual abuse
Single exposure	1.95	0.52	<0.001	5.06	0.95	<0.0001	0.91	0.43	0.04
Repeated exposure	3.07	0.70	<0.0001	4.21	1.29	<0.01	0.50	0.59	0.40
Physical abuse
Single exposure	0.07	0.24	0.78	0.34	0.45	0.46	0.15	0.20	0.46
Repeated exposure	2.79	0.67	<0.0001	2.68	1.20	0.03	−0.34	0.54	0.52
Other trauma
Single exposure	0.36	0.28	0.20	−0.02	0.53	0.98	0.07	0.24	0.78
Repeated exposure	3.32	0.46	<0.0001	3.86	0.83	<0.0001	0.22	0.39	0.57
SLEsb
Total (0–15 years)	0.38	0.12	<0.01	0.45	0.21	0.03	0.24	0.09	0.01
Childhood (0–11 years)	0.10	0.12	0.41	−0.05	0.21	0.82	0.21	0.09	0.02
Adolescence (12–15 years)	0.41	0.12	<0.001	0.68	0.21	<0.01	0.10	0.09	0.26

Abbreviations: B, regression coefficient; CpG, cytosine–guanine dinucleotide; SLE, stressful life events. Linear regression of early life stress and multivariate regression analyses of SLEs in two age categories on NR3C1 methylation scores. Bold numbers indicate significant results (P<0.05).

^aNo exposure is the reference category.

^bZ-scores.