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Knock-out of β-catenin in sensory progenitors inhibits utricular hair cell development. A, Examination of the ear at E17.5 after deletion of β-catenin at E12.5 in Sox2-CreER;β-cateninflox(exon2–6) mice revealed a smaller utricle with less hair cells. B, The decrease in utricular hair cell number and utricular size were significant after β-catenin knock-out from E12.5 to E17.5, E13.5 to E18.5, and E15.5 to P0.5 (p < 0.01). Scale bar, 20 μm.
