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. 2014 May 7;34(19):6480–6484. doi: 10.1523/JNEUROSCI.5073-13.2014

Figure 3.

Figure 3.

Effects of A2A receptor antagonists on self-administration of different doses of THC under an FR10 schedule in squirrel monkeys. A, B, Dose–response curves for THC self-administration after intramuscular pretreatment with SCH-442416 (1 mg/kg) or vehicle. C, D, Dose–response curves for THC self-administration after intramuscular pretreatment with KW-6002 (0.3 mg/kg) or vehicle. The number of THC injections per session (A, C) and overall response rates in the presence of the green light signaling THC availability (B, D) are shown as a function of THC dose. Each data point represents the mean ± SEM of the last three sessions under each THC condition and under vehicle conditions (n = 4). *p < 0.05, **p < 0.01, post hoc comparisons of the effects of pretreatment with vehicle versus SCH-442416 or KW-6002 within each THC dose, Tukey's test. V, Vehicle.