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. Author manuscript; available in PMC: 2014 May 7.
Published in final edited form as: Brain Res. 2012 Sep 13;1483:31–38. doi: 10.1016/j.brainres.2012.09.013

Figure 1.

Figure 1

NPY1 and 2 receptor agonists attenuate the METH-induced NO production in striatal neurons. All animals received aCSF injections in left striata and agonist in right striata 30 minutes prior to systemic injection of METH (30 mg/kg, ip). 3-NT was detected by immunohistofluorescence with the confocal microscope. Note that both agonists demonstrate a significant dose dependent effect on the production of 3-NT in the striatum at 4 hours post-drug treatment (n=6 per group). Analysis was performed from mean ±SEM. Differences between groups and concentrations were analyzed by Two-Way ANOVA. (* p<0.05; **p<0.01; ***p<0.001; **** p<0.0001 relative to aCSF + Saline).