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. Author manuscript; available in PMC: 2014 May 7.
Published in final edited form as: Brain Res. 2012 Sep 13;1483:31–38. doi: 10.1016/j.brainres.2012.09.013

Figure 2.

Figure 2

NPY1 and 2 receptor antagonists enhance the METH-induced 3-NT production in striatal neurons. Low, Mid and High doses under the x-axis refer to concentrations of NPY1 receptor antagonist (BIBP3226: 340, 680 and 1360 μmol) or NPY2 receptor antagonist (BIIE0246: 1, 2 and 4 nmol). 3-NT fluorescent intensity increases in a dose-dependent manner with NPY receptor antagonist administration at 4 hours post-METH (30 mg/kg, ip) treatment (n=6 per group). Analysis was performed from mean ±SEM. Differences between groups and concentrations were analyzed by Two-Way ANOVA and Bonferroni’s post-hoc test. **p<0.01, ***p<0.001 relative to aCSF plus saline. !!p<0.01, !!!p<0.001 relative to aCSF plus antagonist.