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. Author manuscript; available in PMC: 2014 May 7.
Published in final edited form as: Brain Res. 2012 Sep 13;1483:31–38. doi: 10.1016/j.brainres.2012.09.013

Figure 3.

Figure 3

Immunohistochemical co-localization of cyclic GMP with select markers of striatal projection (A) and interneurons (B-D). A), DARPP-32 in projection neurons; B), parvalbumin; C), nitric oxide synthase; and D) cholineacetyl transferase. Mice (n=6) were injected with METH (30 mg/kg, ip) and sacrificed at 4 and 8 hours post-injection. Stained neurons were counted using computerized unbiased stereology and the results normalized relative to saline-treated controls. Note that the percentage of striatal neurons staining positive for cyclic GMP increase between 4 and 8 hours in all neuronal populations except the SST/NPY/NOS interneurons where staining decreased between 4 and 8 hours. Differences between groups were analyzed by Two-Way ANOVA and Bonferroni’s post-hoc test. ***p<0.001; ****p<0.0001.