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. Author manuscript; available in PMC: 2014 May 13.
Published in final edited form as: Brain Res. 2013 Mar 19;1510:38–47. doi: 10.1016/j.brainres.2013.03.010

Figure 1.

Figure 1

SST analogue's modulation of METH-induced nitric oxide. (A) Pretreatment with the SST analogue octreotide (OCT) resulted in a dose dependent attenuation of METH-induced NO synthesis as measured by 3-nitrotyrosine (3-NT) immunohistochemistry (confocal images taken at 63x). Mice (n=6) received intrastriatal infusions of aCSF (right striatum) or OCT (left striatum); followed 15 minutes later by an injection of METH (30 mg/kg, i.p.) or saline. Animals were sacrificed 6 hours after METH treatment. (B) 3-NT immunoreactivity was determined utilizing confocal microscopy and Leica imaging software to measure staining intensity. (***p<0.001 as compared to the aCSF group; #p<0.05, ##p<0.01 as compared to the METH group).