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. Author manuscript; available in PMC: 2015 Apr 14.
Published in final edited form as: Cancer Cell. 2014 Apr 3;25(4):415–427. doi: 10.1016/j.ccr.2014.02.008

Figure 4. 3q21q26 mice develop G2DHE-dependent leukemia.

Figure 4

(A) Kaplan-Meier survival curve of Tg (−) (n=96), 3q26 (n=55), 3q21q26 (n=121) and 3q21q26ΔG2DHE (n=26) mice. Survival rates are calculated by compiling data from multiple Tg mouse lines. The inserted graph shows the overall survival of each line of 3q21q26 mice (lines A, B and C). (B, C) White blood cell counts (B) and hematocrits (C) in the peripheral blood of Tg (−) (n=11-46) and 3q21q26 line A (n=6-19), line B (n=5-15) and line C (n=3-9) mice. (D) Representative smears of peripheral blood taken from Tg (−) and leukemic 3q21q26 mice. Scale bar, 20 μm. (E) The numbers of white blood cells in leukemic 3q21q26 line A (n=6), line B (n=7) and line C (n=3) mice and Tg (−) (n=5) littermates. (F) Representative spleens from Tg (−) and leukemic 3q21q26 mice. Scale bar, 1 cm. (G) Average spleen weights from Tg (−) (n=5) and leukemic 3q21q26 line A (n=6), line B (n=7) and line C (n=3) mice. (H) Hematoxylin-eosin staining of tissues of Tg (−) (top panels) and leukemic 3q21q26 line B (bottom panels) mice. Scale bar, 100 μm.

Bar graphs are represented as mean +/− SD. *, p<0.05; **, p<0.01 compared to Tg (−).