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. 2014 Apr 8;7:67–79. doi: 10.2147/TACG.S45620

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© 2014 Al-Salameh et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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A schematic diagram of the structure of Na⁺/K⁺ ATPase subunit alpha 1 (upper panel, ATP1A1), Ca²⁺ ATPase 3 (middle panel, ATP2B3) and the alpha subunit of low-voltage activated calcium channel Ca_v1.3, with known mutations indicated by red circles (lower panel).

Notes: Upper and middle panels adapted by permission from Macmillan Publishers Ltd: Nature Genetics, Beuschlein F, Boulkroun S, Osswald A, et al. Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension. Nat Genet. 2013;45(4):440–444, 444e1–2.40 Copyright © 2013. Lower panel adapted by permission from Macmillan Publishers Ltd: Nature Genetics, Azizan EA, Poulsen H, Tuluc P, et al. Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nat Genet. 2013;45(9):1055–1060.30 Copyright © 2013.