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. Author manuscript; available in PMC: 2015 Jan 8.
Published in final edited form as: Neuron. 2014 Jan 8;81(1):91–102. doi: 10.1016/j.neuron.2013.10.056

Figure 3. BHQ-modulated Cav2.1 channels exhibit slow deactivation that is greater for ICa than for IBa.

Figure 3

(A) ICa was evoked by 15-ms test pulses from −80 mV to various voltages with repolarization to −40 mV under control conditions or in the presence of BHQ (10 μM). Representative current traces are shown (left). For +20-mV to −40 mV step, the decay of tail currents was fit with a double exponential function. Averaged data (mean ± SEM, right) represent the time constant (τ) and fractional contribution (Fraction) of the fast and slow component. *, p < 0.01 by paired t-test. (B) Representative traces for IBa (left) evoked as in A. Averaged data (mean ± SEM, right) show fast and slow time constants from double exponential fits of the decay of tail IBa (for +10 mV to −40 mV step, n=10) and ICa (n=7) in the presence of BHQ. *, p = 0.03 by t-test. (C) For ICa and IBa evoked as in A,B, tail current amplitudes were measured 5 ms following the repolarization to −40 mV and plotted against test voltage. The percent increase caused by BHQ is indicated for ICa (at +20 mV) and IBa (at +10 mV). Points represent mean ± SEM. See also Figure S2.