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. Author manuscript; available in PMC: 2015 Jan 21.
Published in final edited form as: Chem Res Toxicol. 2013 Dec 19;27(1):111–118. doi: 10.1021/tx400356y

Figure 4.

Figure 4

Hypoxic metabolism of 1b in phosphate-buffered D2O/CD3OD does not lead to incorporation of deuterium into the metabolite 3. LC-MS of the mono-N-oxide metabolite 3 generated by hypoxic metabolism of 1b. Panel A, isotope cluster for the [M+H]+ ion of 3 generated in phosphate-buffered H2O/CH3OH (relative peak intensities for m/z 148:149:150 = 100:7.9:0.5). Panel B, isotope cluster for the [M+H]+ ion of 3 generated in phosphate-buffered D2O/CD3OD (relative peak intensities for m/z 148:149:150 = 100:8.2:0.6).