Table 4.

Multivariate analysis of factors associated with persistent villous atrophy on follow-up biopsy.^*

Characteristic	OR for persistent villous atrophy (95% CI)	p value
Age at follow-up biopsy (years)		0.0019
0.5–9	1.0 (ref)
10–19	1.31 (0.81–2.10)
20–29	1.03 (0.56–1.89)
30–39	1.52 (0.89–2.58)
40–49	1.70 (0.98–2.94)
50–59	1.43 (0.85–2.40)
60–69	2.00 (1.19–3.38)
≥70	3.64 (2.01–6.59)
Sex		0.0155
Male	1.43 (1.07–1.90)
Female	1.0 (ref)
Education level		0.0073
< 2 years of HS	1.0 (ref)
2 years of HS	0.93 (0.62–1.39)
3 years of HS	0.63 (0.40–0.99)
College/University	0.52 (0.35–0.78)
Histology on index biopsy		0.4733
Partial villous atrophy	1.0 (ref)
Subtotal/total villous atrophy	1.24 (0.80–1.90)

^*Restricted to patients whose follow-up biopsy was performed during the years 2000–2008, 2–5 years after initial CD diagnosis