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. 2014 Apr 4;12(4):2132–2143. doi: 10.3390/md12042132

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Electrophysiological characterization of Compound 9 under voltage clamp (A) and patch clamp (C) conditions. (A) Representative whole-cell current traces of Na_V1.4 and Na_V1.5 in the control and 1 μM of Compound 9 conditions are shown. The asterisk (*) marks the steady-state current traces after the application of 1 μM of Compound 9. (B, left panel) At a 1-μM concentration of Compound 9, no significant alteration in the characteristics of activation or inactivation was observed; (B, right panel) The concentration-response curve of Compound 9 for Na_V1.4 channels. The IC₅₀ value yielded 3.5 ± 0.9 μM. (C) The representative current traces of Na_V1.4 in the control and 10 μM of Compound 9 conditions are shown in the resting state (left panel) and the inactivated state (right panel). The asterisk (*) marks the steady-state current traces after the application of 10 μM of Compound 9.