Distribution of putative miPs across taxa and TF families. A, Distribution of putative miPs (expressed in absolute numbers) predicted to affect TFs across microbes (blue bars), plants (green bars), and animals (red bars). B, Distribution of putative miPs across target TF families in archaea and bacteria (Methanocaldococcus jannaschii DSM 2661, Escherichia coli, and Synechocystis sp. PCC 6803), yeast, C. reinhardtii, plants (P. patens, Selaginella moellendorffii, Oryza sativa, Populus trichocarpa, Arabidopsis, Glycine max, and Zea mays), and metazoans (C. elegans, D. melanogaster, Danio rerio, Xenopus tropicalis, Gallus gallus, M. musculus, and H. sapiens).