Fig. 5. CHI3L1 KO mice are less susceptible to AIEC infection and produce lower amounts of IL-6 and IL-22.
(A) Colonic cryo-sections of 1% DSS treated non-infected or AIEC LF82 infected WT and CHI3L1 KO mice were stained with anti-Escherichia coli LPS-specific antibody at day 14 post-infection. (10× objective) (B, C) Quantification of ampicillin resistant AIEC LF82 bacteria in non-infected (CT) or infected (AIEC) WT and Brp39 KO mice was examined. Organ load of LF82 in spleen, mesenteric lymph nodes (MLN), liver, and colon (B) and productions of TNFα, IL-6, and IL-22 in colon (C) are shown among the above groups of mice (n=6 in each group). *P<.05, **P<.01 and NS, no significant difference.