Table 5.
Effect of Simvastatin and Traumatic Brain Injury (Vehicle/Sham) on Genes of Interest (1.5 Fold Change, p<0.05)
| Simvastatin | Vehicle | |||
|---|---|---|---|---|
| Affymetrix ID | Gene symbol | Genes | Vehicle | Sham |
| 72 h | ||||
| 10739035 | Ace | angiotensin I converting enzyme (peptidyl-dipeptidase A) | 0.62 | 1.85 |
| 10930539 | Adcyap1 | adenylate cyclase activating polypeptide 1 | 0.60 | n.s. |
| 10798194 | Agtr1a | angiotensin II receptor, type 1 | 0.45 | 4.17 |
| 10775968 | Alb | Albumin | 1.85 | 0.49 |
| 10744425 | Alox15 | arachidonate 15-lipoxygenase | 2.83 | n.s. |
| 10736712 | Ccl12 | chemokine (C-C motif) ligand 12 | 1.55 | 1.60 |
| 10745677 | Ccl3 | chemokine (C-C motif) ligand 3 | 1.67 | 2.97 |
| 10736702 | Ccl7 | chemokine (C-C motif) ligand 7 | 1.76 | 10.83 |
| 10757632 | Ccl24 | chemokine (C-C motif) ligand 24 | 2.07 | 1.77 |
| 10921163 | Ccr1 | chemokine (C-C motif) receptor 1 | 1.90 | 4.29 |
| 10914614 | Ccr2 | chemokine (C-C motif) receptor 2 | 1.66 | 13.15 |
| 10775896 | Cxcl2 | chemokine (C-X-C motif) ligand 2 | 2.06 | n.s. |
| 10887947 | Cyp1b1 | cytochrome P450, family 1, subfamily b, polypeptide 1 | 0.62 | 6.77 |
| 10781404 | Dok2 | docking protein 2 | 1.51 | 1.89 |
| 10794734 | F13a1 | coagulation factor XIII, A1 polypeptide | 1.86 | 1.99 |
| 10811126 | Fa2h | fatty acid 2-hydroxylase | 0.66 | n.s. |
| 10814286 | Fabp4 | fatty acid binding protein 4, adipocyte | 1.67 | 4.40 |
| 10804127 | Fgf1 | fibroblast growth factor 1 | 0.63 | 1.73 |
| 10935811 | Gabre | gamma-aminobutyric acid (GABA) A receptor, epsilon | 0.64 | 2.22 |
| 10742820 | Glra1 | glycine receptor, alpha 1 | 0.49 | 5.47 |
| 10842657 | Gnas | GNAS complex locus | 0.65 | 1.83 |
| 10823412 | Gpr149 | G protein-coupled receptor 149 | 0.64 | n.s. |
| 10724315 | Hbb | hemoglobin, beta | 1.65 | n.s. |
| 10724319 | Hbb-b1 | hemoglobin, beta adult major chain | 1.77 | n.s. |
| 10910473 | Hcn4 | hyperpolarization activated cyclic nucleotide-gated potassium channel 4 | 0.52 | 2.01 |
| 10918979 | Htr1b | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | 0.62 | n.s. |
| 10729791 | Ifit1 | interferon-induced protein with tetratricopeptide repeats 1 | 1.77 | n.s. |
| 10888131 | Kcng3 | potassium voltage-gated channel, subfamily G, member 3 | 0.56 | n.s. |
| 10760290 | Nptx2 | neuronal pentraxin II | 0.59 | n.s. |
| 10815655 | Npy2r | neuropeptide Y receptor Y2 | 0.57 | 3.42 |
| 10866030 | Olr1 | oxidized low density lipoprotein (lectin-like) receptor | 1.55 | 11.06 |
| 10764551 | Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.63 | 2.60 |
| 10856474 | Reg3b | regenerating islet-derived 3 beta | 0.66 | 2.07 |
| 10824695 | S100a9 | S100 calcium binding protein A9 | 1.74 | 2.23 |
| 10765186 | Sell | selectin L | 1.66 | 4.04 |
| 10874981 | Sulf1 | sulfatase 1 | 0.66 | 1.84 |
| 10853683 | Tac1 | tachykinin, precursor 1 | 0.53 | n.s. |
| 10770577 | Tgfb2 | transforming growth factor, beta 2 | 0.60 | 1.98 |
| 7 days | ||||
| 10729269 | Anxa1 | annexin A1 | 1.64 | 5.84 |
| 10843229 | Cacna1b | calcium channel, voltage-dependent, N type, alpha 1B subunit | 0.64 | 0.66 |
| 10746327 | Cacna1g | calcium channel, voltage-dependent, T type, alpha 1G subunit | 0.65 | n.s. |
| 10725051 | Calca | calcitonin-related polypeptide alpha | 1.72 | n.s. |
| 10907834 | Casp12 | caspase 12 | 1.58 | 2.31 |
| 10736697 | Ccl2 | chemokine (C-C motif) ligand 2 | 2.09 | 13.29 |
| 10745677 | Ccl3 | chemokine (C-C motif) ligand 3 | 1.55 | 2.77 |
| 10736863 | Ccl4 | chemokine (C-C motif) ligand 4 | 1.54 | 1.54 |
| 10736702 | Ccl7 | chemokine (C-C motif) ligand 7 | 2.47 | 1.59 |
| 10736712 | Ccl12 | chemokine (C-C motif) ligand 12 | 1.83 | 1.69 |
| 10914614 | Ccr2 | chemokine (C-C motif) receptor 2 | 1.88 | 4.33 |
| 10803991 | Cd14 | CD14 molecule | 1.90 | 4.41 |
| 10853240 | Cd36 | CD36 molecule (thrombospondin receptor) | 1.74 | 2.83 |
| 10923052 | Col3a1 | collagen, type III, alpha 1 | 1.59 | 2.90 |
| 10887622 | Crip1 | cysteine-rich protein 1 (intestinal) | 1.84 | 1.58 |
| 10771660 | Cxcl9 | chemokine (C-X-C motif) ligand 9 | 1.52 | 1.60 |
| 10771655 | Cxcl10 | chemokine (C-X-C motif) ligand 10 | 1.96 | 6.47 |
| 10771649 | Cxcl11 | chemokine (C-X-C motif) ligand 11 | 1.87 | 4.43 |
| 10845681 | Fap | fibroblast activation protein, alpha | 1.62 | 1.56 |
| 10844005 | Fcnb | ficolin B | 1.58 | 2.72 |
| 10909874 | Il18 | interleukin 18 | 1.59 | 3.21 |
| 10834109 | Il1rn | interleukin 1 receptor antagonist | 1.68 | 2.39 |
| 10734952 | Kcnab3 | potassium voltage-gated channel, shaker-related subfamily, beta member 3 | 0.66 | n.s. |
| 10890609 | Kcnh5 | potassium voltage-gated channel, subfamily H (eag-related), member 5 | 0.54 | n.s. |
| 10904329 | Kcnk9 | potassium channel, subfamily K, member 9 | 0.66 | 0.66 |
| 10903585 | Kcnv1 | potassium channel, subfamily V, member 1 | 0.66 | 0.50 |
| 10841693 | Lbp | lipopolysaccharide binding protein | 1.93 | 2.84 |
| 10844331 | Lcn2 | lipocalin 2 | 1.83 | 5.81 |
| 10781304 | Loxl2 | lysyl oxidase-like 2 | 1.64 | 3.16 |
| 10912439 | Rbp1 | retinol binding protein 1, cellular | 1.52 | 2.92 |
| 10817053 | S100a3 | S100 calcium binding protein A3 | 1.99 | 2.76 |
| 10817057 | S100a4 | S100 calcium-binding protein A4 | 1.69 | 4.37 |
| 10817065 | S100a6 | S100 calcium binding protein A6 | 1.54 | 2.27 |
| 10765186 | Sell | selectin L | 1.73 | 2.02 |
| 10860481 | Sema3a | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.64 | 0.66 |
| 10886621 | Serpina3n | serine (or cysteine) peptidase inhibitor, clade A, member 3N | 2.16 | 4.01 |
| 10761047 | Serpine1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 3.05 | 2.29 |
| 10852595 | Sox18 | SRY (sex determining region Y)-box 18 | 1.50 | n.s. |
| 10934865 | Srpx2 | sushi-repeat-containing protein, X-linked 2 | 1.55 | n.s. |
| 10874981 | Sulf1 | sulfatase 1 | 1.53 | n.s. |
| 10797138 | Tgfbi | transforming growth factor, beta induced | 1.63 | 2.25 |