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. Author manuscript; available in PMC: 2014 May 7.
Published in final edited form as: Curr Pharm Des. 2013;19(19):3529–3541. doi: 10.2174/13816128113199990321

Fig. (5).

Fig. (5)

Synthesis of GlyH-101 and SAR analysis. A. (a) Ethyl iodoacetate, NaOAc, H2O, 90 °C, 3 h, 65%; (b) EtOH, N2H4, reflux, 82%; (c) 3,5-dibromo-2,4-dihydroxybenzaldehyde, EtOH, 3 h, 78%. B. SAR showing requirements for CFTR inhibition activity. Adapted from ref. 40.