Figure 1.

Synergism of co-delivery. A) Depiction of the synergistic mechanism of the co-delivered drugs DOX and AGM (left). Synergistic cytotoxic effect of linear HPMA copolymer-DOX-AGM when compared to conjugated DOX or combination delivery of separately-conjugated DOX and AGM (right). Reprinted¹⁸ with permission from Elsevier. B) Synergistic mechanism of the co-delivery of DOX and siRNA targeting the Bcl-2 gene (left). The synergistic impact on ovarian cancer cell viability of liposomal co-delivery of DOX and Bcl-2 siRNA (right). Reprinted¹¹ with permission of John Wiley and Sons. C) Liposomal co-delivery of therapeutic plasmid pEGFP-hTRAIL and paclitaxel yields an increase in survival time for glioma-bearing mice. Reprinted¹⁶ with permission of Elsevier.