Figure 1.

Cell and/or tissue injury (e.g. necrosis) trigger mitochondria DAMPs (mtDAMPs) release. MtDAMPs are potent immunological activators due to the bacterial ancestry and once released from necrosis they can lead to vascular damage. F-MIT (mitochondria-derived formyl peptide); mtDNA (mitochondria DNA); TLR 9 (Toll like receptor 9); FPR (formyl peptide receptor); P2 (purinergic receptor); ATP (adenosine triphosphate); mtRNA (mitochondrial RNA and microRNA); TFAM (mitochondrial transcription factor A).