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. 2013 Feb 19;5(5):1290–1303. doi: 10.18632/oncotarget.1789

Figure 6. As3+-induced Myc expression is JNK-dependent.

Figure 6

(A) Dose-dependent induction of Myc protein by As3+. As3+ is unable to induce Oct4, Sox2 and Klf4 in both the parental cells (BEAS-2B) and the transformed cells (Transf). (B) Myc induction in the parental cells is correlated with JNK activation in response to lower concentrations of As3+ for 72 h. (C) Inhibition of JNK by JNK inhibitor SP600125 (SP) prevented Myc induction by As3+. (D) Silencing JNK by siRNAs specific to JNK1 or JNK2 inhibited As3+-induced Myc expression.