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. 2014 Mar 20;5(5):1382–1389. doi: 10.18632/oncotarget.1837

Figure 2. Endothelial integrin α3β1 stabilizes tumor/endothelial cell adhesion.

Figure 2

A, Tumor/endothelial cell adhesion undergoes rapid stabilization. Note rapid increase in a wall shear stress required to displace 50% of stably adhered tumor cell after 10, 15, 20, and 30 min of incubation with endothelial monolayers. B, Function blocking anti-α3β1 antibody P1B5 (blue bar) does not affect the initial adhesion of tumor cells to the endothelium after 10 min of incubation compared with control IgG (black bar). C and D, Anti-α3β1 function blocking antibody P1B5 inhibits tumor/endothelial cell adhesion stabilization. C, Compared with control IgG (black bar), anti-α3β1 antibody P1B5 (blue bar) reduces significantly the wall shear stress required to displace 50% of stably adhered tumor cell after 10 min of incubation. D, Compared with control IgG (black bars), anti-α3β1 antibody P1B5 (blue bars) increases significantly the percent of tumor cells displaced by the wall shear stress of 20 and 40 dynes/cm2 after 10 min of incubation. In A thorough D, data presented as means ± STDEV; *denotes statistical significance (p<0.05)