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. 2014 Mar 16;5(5):1352–1362. doi: 10.18632/oncotarget.1817

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Copyright: © 2014 Tang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Analytical HPLC profiles (mAU at 220 nm) of HepIn-13 which was dissolved in the mouse blood plasma at indicated concentrations and then extracted and analyzed by HPLC. (B) Blood concentrations of HepIn-13 at indicated time points after tail vein injection of 1 mg of the compound. Data are the means of three independent experiments ±SD. (C) HepIn-13 is orally bioavailable. Analytical HPLC profiles (mAU at 220 nm) of blood plasma extracts: from tail vein injected with HepIn-13, untreated and oral gavage treated mice. (D) Mass Spectrometry confirmation of the presence of HepIn-13 in blood plasma in the peak highlighted by arrow in panel C.