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. Author manuscript; available in PMC: 2014 May 7.
Published in final edited form as: Nat Genet. 2012 Dec 9;45(1):83–87. doi: 10.1038/ng.2497

Figure 2. Accumulation of Nbr1-positive puncta in skeletal muscle of Vici patient.

Figure 2

Transverse sections from muscle biopsies from a normal control (bottom panel) and Patient 3.1 (top panel) were stained with monoclonal antibody against Nbr1 (green channel), polyclonal MURF2 antibody (red channel), and counterstained with the anti-titin M-band antibody T-M8ra (blue channel). Accumulation of Nbr1 in puncta (autophagosomes, arrowheads in top panel), and of MURF2, as well as fibre inhomogeneity with marked fibre atrophy characterise Vici muscle. Numerous fibres of very small cross-sectional area (arrows in top panel) with high content of MURF2 and Nbr1 puncta are frequently seen. Scale bar: 10 μm.