The responses of the PBMCs and SFMCs from RA patients to viral peptides and autoantigen peptides. Compared to the PBMCs from healthy donors, EBVgp110 and HLA-DR4 induced a more significant proliferation of PBMCs and SFMCs from RA patients. SFMCs had the strongest reactive efficacy (all experiments were repeated three times). cpm, counts per million; EBV, Epstein–Barr virus; PBMC, peripheral blood mononuclear cell; RA, rheumatoid arthritis; SFMC, synovial fluid mononuclear cell; TT, tetanus toxin; TTp, tetanus toxoid peptide.