Table 2. AP-1-dependent miRNAs.
miRNA | Stimulus | Alteration | Transcription factors | Cell lines | Reference |
---|---|---|---|---|---|
miR-21 | PMA; ectopic expression of HER2/neu | Up | c-Fos; c-Jun | Side population cells from various cancer cell lines; human breast cancer cell line; human promyelocytic leukemia cell line | 40, 41, 95 |
miR-155 | B-cell receptor cross-linking | Up | FosB and JunB | Human lymphoma cell | 43 |
miR-146b | The two PDGF ligands AA and BB | Up | c-fos | Human glioblastoma and ovarian cancer cells | 42 |
miR-99a | The tyrosine kinase c-Src | Down | ND | Human c-Src-transformed cells | 44 |
Abbreviations: ND, not determined; PDGF, platelet-derived growth factor; PMA, phorbol 12-myristate 13-acetate.