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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Chem Biol Drug Des. 2013 Oct 30;83(2):237–246. doi: 10.1111/cbdd.12233

Fig. 6.

Fig. 6

Allosteric sites 5 and 6 are located between TM7 (red)-TM1 (green)/TM2 (orange) in the lipid-exposed extracellular and intracellular regions, respectively. The key residues that interact with bound probes (ball-and-sticks) are labeled and highlighted in purple for (B) Site 5 and (C) Site 6 in the intermediate 2 conformer.